منابع مشابه
An end in sight: tropomodulin
TIN filaments are required for cell locomotion and numerous intracellular activities in nonmuscle cells, and are a major component of the contractile apparatus in muscle cells. An understanding of the dynamics involved in the assembly and disassembly of actin filaments is fundamental to understanding many cellular functions. In this issue of The Journal of Cell Biology, Weber et al. (1994b) pro...
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Microtubules are intrinsically polar structures. A consequence of this polarity is that the two ends of the microtubule polymer exhibit different properties. The more dynamic plus ends and the mechanisms that regulate their behavior have been the focus of much recent attention. Here, we concentrate on the dynamics and regulation of minus ends, which play distinct but equally critical roles in m...
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All morning, a stream of people walked over rough dirt roads to a health clinic tucked next to a corn fi eld in Paluntar village in western Nepal. Frail elderly women wrapped in saris walked barefoot for hours to reach the four-room clinic. Wizened elderly men in topis, traditional Nepalese hats, carried canes and umbrellas to shade themselves from the hot May sun. By 10am, more than 60 people,...
متن کاملJuniors' hours: is the end in sight?
The question of how to reduce junior doctors' hours has taxed the government and hospital managers for nearly two decades. Now regional task forces are being asked to get them down to a maximum of 83 a week by 1 April next year. From a comparison of the way in which two different task forces (Northern and North West Thames) have responded to the challenge it emerges that most units will probabl...
متن کاملSight at the end of the tunnel
when the chaperoned protein is released. The long-awaited structure of the triggerfactor chaperone,presented by Ferbitz et al., reveals an extended arrangement of three domains — a ‘crouching dragon’with a head, tail and arms — and a notable hydrophobic surface in the shape of a cradle that is exposed in the hollow between the tail and arms. Excitingly, Ferbitz et al. place this in a functional...
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ژورنال
عنوان ژورنال: Nature
سال: 1980
ISSN: 0028-0836,1476-4687
DOI: 10.1038/286434a0